| Inhalte: |
Module Systems Biotechnology
By Prof. Thomas Walther, Chair of Biochemical Engineering, TU Dresden, Germany
Temporal Planning:
Weekly lectures and practicals/tutorials on Mondays and Tuesdays, each 14h50 - 16h20 CET.
Lecture room is ZIN025 at the Institute of Natural Materials Technology, Bergstraße 120, Dresden.
Videos of the lectures will be available online. Possibly, lectures will be streamed (to be decided). Free registration is required for access.
Language of instruction:
English
Content:
The course covers the typical systems biology methods used during strain development for biochemical engineering applications.
The lecture mainly covers the following chapters:
- Stoichiometric analysis of metabolic networks (Flux Balance Analysis, Elementary Flux Mode Analysis).
- 13C-based metabolic flux analysis
- Concepts for mathematical modelling of the regulation of metabolic pathways (Metabolic Control Analysis)
- DNA engineering for optimization of protein expression
- Execution and evaluation of transcriptome analyses (next generation sequencing, hierarchical clustering, functional genomics)
The lectures are accompanied by computer exercises in which the students are familiarized with various software programs:
- CellNetAnalyzer for stoichiometric analysis of metabolic networks.
- 13C-Flux and OMIX for the analysis of metabolic flux experiments
- COPASI for metabolic control analysis
- R for statistical analysis of transcriptome studies
The course is intended for interested students of biochemical engineering and students of biological disciplines.
|
